I've been running around with a N/Me in PvE, focusing on hexes (after getting Soul Bards) to be a hex spammer and ended up with a degen build (well, close enough).

I find the degen N/Me to be effective in PvE and currently using...
Vampiric Gaze, Life Siphon, Soul Barbs, Parasitic Bond, Faintheartedness, Conjure Phantasm, Empathy, Res Sig...
Although I like Empathy, I'm going to give Phantom Pain a try, that way I'll get to remove the points in Domination to boost the other attributes.
With what I have at the moment, I think I can get 10 pips degen on one foe. I like to get the most out of Soul Barbs by unloading as many hexes as I can within the duration... For multiple foes, I try to focus on 2 to get 3 degen hexes on each, and then cycle between them, hitting them with whatever skills that has recharged... It's effective for putting down a single foe, or to weaken many to make it easier for others to finish the job.
I haven't got Life Transfer yet or some of the other skills mentioned in this thread, kinda in the early stages of Post-Searing, but a degen N/Me has worked well for me so far. Life Siphon, Conjure Phantasm, Soul Barbs, and Faintheartedness can be obtained easily (and early on) so you can pretty much have a degen N/Me in Pre-Searing... I probably had the easiest Charr hunting trips across the wall with this build...
