I was capturing some skills this weekend and it occurred to me that in RP terms, our characters are sociopaths. It's as if our characters are in the Sunspear sanctuary and say "Hey, there's a captain in the Arkjok Ward with a neat spell, let's bag him." Death isn't permanent for our characters, but it seems to be with the enemies.
Then there's the EotN mission, "Frog Stomp", where you help the Paragon, Hayda, massacre hekets -- five groups. I know everything resets in Guild Wars, so you'll encounter the same enemy the next time you play, but I hope in GW 2 there will be consequences for our actions. Maybe killing someone will have permanent effects.
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It wouldn't work in GW1 really, but it could work in GW2. For example, killing Frogs would increase their hate, and doing quests/events for them would eventually get you some froggy friends.