I played GW solid from the release of Prophecies through Nightfall. I stopped playing right before EotN came out. I got bored. Ran out of stuff to do.
Fast forward to a couple months ago, when I reinstalled and started up again.
There's TONS to do now. I mean, I could write up a few different checklists for a few different toons... there's a lot to keep me busy.
Domain of Anguish has a healthy population, and its meta for normal mode will accept any class. Urgoz and Deep were empty last time I was there. FA and JQ are not as buys as I'd like, but not terribad. The daily Zaishen Mission, Bounty and Combat always sends some traffic to the area, mission or arena of the day.
To answer your question directly: Yes, Guild Wars is worth picking back up again. You'll probably have a lot of birthday presents waiting for you.
Also:
http://hom.guildwars2.com/ <--work on your legacy
