Run down as in abandoned?
Just draw a normal city, then lop off parts of buildings, add wreckage here and there, and mute the colors so it looks more lifeless. Perhaps you can add parts that had cloth, like storefronts with awnings, and leave the cloth out, as if it had been destroyed/rotted away. Make it look unlived in - knock stuff over; leave fountains empty, that kind of thing. Leave a big empty street in the middle, perhaps; maybe a broken down car or two. Fallout can give some good ideas; you could look at screens of that.
That's my suggestion, anyway.
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