Yaaay, a budding artist!
There are two main ways to do this: you can do it the old-fashioned way (paper and pencil) and scan it, or you can draw it on the computer.
If you're going traditional, you can do everything on paper if you want, though I know from personal experience that some coloring methods (namely colored pencils) suffer greatly going through a scanner. Just remember to make everything dark enough and solid enough (no graininess), and it should come out all right.
If you're going digital, you have a few options. You can sketch it on paper first, scan, and polish (I believe this is how Makani operates) or you can draw it entirely on the computer. For programs, I personally use the freebie "Essentials" version of Corel Painter that came with my tablet, and it works great, but I know a lot of people like Photoshop (I've done a thing or two in Elements but don't have a lot of experience). There's also Adobe Illustrator, which is vector graphics and which my mom keeps pushing me to use, but I don't like it much (it keeps smoothing out my lines! anyone know how to disable that?). About a tablet - tablets are preferable if you're going to be drawing on the computer, because they let you simulate drawing normally as opposed to fighting a mouse; I use an Intuos3. However, I did know one person who produced truly spectacular drawings with a mouse. She (he?) was back on KFM and I can't quite remember the name; I'd have to look it up. So it is possible, but know that it'll be quite hard.
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