Shiro is easy, just get someone to tank him(video of me doing it in Assassin forums and Screenshots) and getting up to him is really easy if your team isn't a bunch of idiots.
In fact, the entire RoT can be run through rather quickly with heros. The nightfallen Jahai quest can be solo run fairly easily, as well as the gate of secrets. Gate of pain can be done with heros and Gate of Madness is relatively easy to get up to the end with a good team.
If you can't handle that, wait until you beat the game and see DoA. You haven't seen anything until you've had to fight off mobs of 20+ level 28-30s that run faster than you and kill you in one hit.
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