I'm pretty sure you can already change the keys to change weapon sets from in the game. It seems rather basic but if you don't want basic then i don't see how it will be any faster.
I currently run GuildWars on my MBP with the multitouch trackpad. Using an external program I have set up so that different swipes do different things e.g. a 3 finger swipe right would switch to the next target while a 3 finger swipe left would go to the previous target. Doesn't seem like anyone will get in trouble for things like these unless you record an advanced macro that makes you a semi-bot like an auto-build thing that targets and activates skills without you having to do anything.
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