You'll survive easier when battling less enemies, and since they don't always come in low numbers it's best to quickly cut down a few of them yourself.
I myself find the melee attackers in PvE rather weak, so I don't need to worry about a lower HP when battling them. The main problem in PvE are imo the casters and the condition dealers. Mainly the elementalist' Mind Burn combined with the poison and bleeding from Assassins and Rangers (The part I hate about Faction, when not having a good Condition remover in your team and when you can't remove them yourself).
Praise Nightfall for introducing Mending Touch and overpowering almost every Monk related build in the game _0_ .
Anyway, the casters in the game are easy to take care of IF you have the AP's to cut them down in 1, 2 or maybe 3 hits. That means one opponent less, which already makes up for the 75 HP lost.
And if you like HP so much, it is better to play a Dervisch or use a Vigor Rune + a shield and weapon that ad's HP.
16 Sword/Axe Mastery ftw btw.
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