Hi!
I'm assuming your character is recently arrived in Post-searing.
Major runes are pretty useless. They aren't worth the HP loss. Minor or Superior are the way to go.
Corwen the armor crafter in Ascalon City is a must-buy-from. You will need to farm a bit unless you already have the materials. You can turn wood into parchment outside Sardelac Sanitarium, and salvaging what you pick up generates tanned hides, wood, iron (all valuable), and less valuable stuff as well.
My Necro/Monk was able to solo a fair amount relying on Rotting Flesh, Deathly Chill, Animate Bone Horror, Heal Area, and not much else. Rotting Flesh may be gotten a little later on, but my wife helped me fight to the Shiverpeaks quickly. I think the others are skills you get very early on, and the Rotting Flesh isn't really needed.
Guildwiki.org is the place to look for detailed lists of skills, where you get them, etc. Its search function is lousy, so search using regular Google (and put the word "guildwiki" into your search string).
Hmm. Without /Mo you'll have no way to heal minions for a while. Well, I think that will matter less than one would think.
My Ele/Me early on soloed most of Ascalon. But he had Aura of Restoration and Ether Feast for self-healing, which you don't have available. And Blood Magic is fairly weak on self-healing.
I'd say you should get Soul Feast as soon as you can, from the Fallen Soldiers quest that you get in Pikens Square. It's the one really good self-heal available to you, and self-healing is crucial if you have a bias to playing solo.
Oh yeah -- the gargoyles right outside Nolani Academy are wonderful to gain XP or even a bit of cash from.
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