No. You can have empty hands or daggers, or even a hammer and still cast spells. Equipment will never prevent you from casting spells.
You could also go A/W, and get watch yourself (for added defense, and for an assassin, its easy to get adrenaline), and wild blow (removes stances, auto critical hit). Critical Defense and Way Of Perfection work very well with Wild Blow.
Do not overstay your welcome, so get in, do your combo and get out. Staying in the fray too long will get you unwanted attention.
Initially I went A/Mo - for condition removal and hard rez. Also a long lasting enchantment was good as well. Then I changed to A/N for long lasting hexes like PB and plague touch. Then I went to A/W for balanced stance and wild blow, as I now have long lasting enchantments, hexes and condition removal.
The only thing an Assassin lacks is a hard rez and a hex removal.
Good luck and enjoy.
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