Runes would be Sup Axe Mastery, Minor Tactics, Minor Strength, and the best Vigor And Absorbtion you can get. Thats for a normal build.
For farming Anti-Melee creatures it's the same, otherwise it depends on what you intend on farming.
Running builds usually consist of Sprint, Endure Pain, Healing Signet. These key skills are strength and tactics so you will need a Strength or Tactics helm, and you should have a rune for those already.
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