Please don't take this as a bash to your almost complete build.
Illusion Magic - Fragility
Death Magic - Virulence
Blood Magic - Signet of Agony
Plague Sending and Empidemic are basically 0 attribute points (Epidemic is associated with 0 attributes, while Plague Sending is part of curse, but you only need 0 points to make it work).
With 3 attributes already and Soul Reaping still available, you are spreading your attributes too thin. With no healing, you lose 20% of max life and suffer bleeding for about 2 seconds.
Now, lets assume that Signet of Agony's main and only purpose is to bleed, so the damage inflicted doesn't matter. So that would mean 0 points into Blood magic, which is fine then.
In PvE, this is very effective against anything that bleeds. Monsters that have "no flesh", this becomes utterly useless, as all conditions but weakness will affect monsters (but you need a condition first to inflict Virulence).
Unfotunately, monsters don't always stay near each other often, so epidemic can be used speratically at best.
From what I've heard about PvP (as I don't play that), disease can affect you and your group (coming in contact with the opposing side). This doesn't happen in PvE though.
Also in PvP, monks and ritualists can easily stop the spread of bleeding and any other conditions you inflict with ease. That and the fact that people are smarter (tend to be anyway) and will not bunch up together.
These are just points of concerns, and remember, you do need self-heals.
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