If you are having a problem with timing interrupts, then you can use arcane conundrum or migraine to slow down the enemy's casting speed to give you more time to interrupt. To interrupt effectively you need to be familiar with pretty much all the spells out there and know which spells can or cannot be interrupted by looking at the skill icons (i.e. Reversal of Fortune is 3/4 cast time - almost impossible to interrupt without conundrum, some of the necro touch spells are classified as skills instead of spells - these cannot be interrupted, etc.)
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