In presearing, anything works. I prefer Mo/R (prior to finalizing secondaries) simply because I can get a pet. In early postsearing (pre-desert), I feel Mo/Me offers the most by getting some decent energy management in inspiration. In late postsearing (post-desert when you get the first chance for elites), you can change your secondary if you really want to for Mo/N to get Offering of Blood, but for PvE, Mesmer still works. Until you get to Yak's Bend, you pretty much need to go half protection/half healing because of your limited skills. Once you get there though, I find a boon protector to be most effective. This is because you can heal and protect at the same time. You can search for builds, but basically use Divine Boon, Reversal of Fortune, and Guardian (purchased in Ascalon I believe). Play the game and find the build you like in the desert and after.
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