I think Curses work better with a Mesmer. Some of them like Soul Barbs do damage everytime you cast a Hex on an opponent. Since you'll pretty much always be casting Hexes on them, they kind of go together.
If you insist on using Blood then...I'd probably only take a few Blood skills for support, like wells or life-stealing things, and then the rest of my skills would be Domination.
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