just keep in mind that everything anyone says about the farm code is speculation, the anti-farm specifics are a tightly guarded secret of Anet.
That being said, it is generally true that doing multiple consecutive runs will reduce your drop quality over time, and doing missions undoes this effect.
Its up to you to find a balance. I usually farm greens, so I am spending a moderate amount of time in multiple zones. This would possibly lead to me having less anti-farm than someone who was farming the same area over and over.
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