I'm left handed and have been that way my entire life in most aspects. Personally when it comes to mobility on the computer I've never had a problem with typical keyboards. I mean, left hand is on the left, right hand on the right, they both have to learn the movements anyway =P.
A mouse may be different, but in most cases you can swap a mouse to the left side or if you're using a pad just use your left hand. As for GW movement, I prefer to use skills on the number bar with my left hand, so I usually do primary movement (up, down, left, right) on the arrows and strafe/use skills with left hand.
Only thing I can really see a need for "left hand specific" would be a left handed gaming mouse that's otherwise contoured for the right hand.
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