Best place to chest run in the realm of Torment is the Domain of Secrets. Behind the outposts (either one) there is a large area filled with terrorweb dryders. It's here that you ahve a chance to get rare inscibable version of previously uninscribable attractive skins like storm bow, eternal shield, and ghostly staff.
Its not the easiest or fastest chest run, but its the run with the best loot.
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