Btw, I don't think the volume knob relies on the key profiler to work. But, if you were suggesting that I bind some G-keys to do volume functions - I haven't tried it, but from what I've read, that doesn't work either.
I have discovered that the volume roller still works on the Skyrim startup screen, which is usually about the point I remember to turn it up.
The more I play Skyrim, the less attractive it becomes. Too many glitches, bad animations, controls suck, targeting sucks. I don't think GW2 needs to worry.