Yes and no. Some quests that rewards with skills will not be repeatable, but there will be a few that will become available when you change your secondary. e.g. In Piken Square (Prophecies), A ranger quest becomes available, when you change your 2nd to ranger. Also, "Replacement Monks", in Serenity Temple, when you change to monk 2nd. Some Mesmer and Necro in Sardelac Sanitarium. There could be others scattered here and there around the map. There is a list of quests that rewards skills somewhere on wiki that will guide you. Perhaps someone can locate it and reference it for you.
Thank you Cosy!
Last edited by Perkunas; Jul 25, 2012 at 03:23 PM // 15:23..