You could follow the primary questline with all the missions, and skip the peripheral quests.
But you could also complete all the quests as you go, if you want. There is a lot of good lore, and great music, along the way. Also you might find others need the same quests, and you could meet people by teaming up.
I remember my first toons doing every single quest in Old Ascalon. Got so sick of that ugly landscape, it made it that much sweeter to get to the next area when the time came.